A comparison of the ballistic behaviour of conventionally sintered and additively manufactured alumina

Production of ceramic armour solutions on-demand/in-theatre would have significant logistical and military advantages. However, even assuming that such technologies could be successfully deployed in the field, such near net-shape manufacturing technology is relatively immature compared to conventional sintering of ceramics. In this study, the ballistic performance of a series of additively manufactured (AM)/rapidly-prototyped (RP) alumina tiles of 97.2% of the density of Sintox FA™ were investigated using both forward- and reverse-ballistic experiments. These experiments, undertaken with compressed gas-guns, employed the depth-of-penetration technique and flash X-ray as primary diagnostics to interrogate both efficiency of penetration and projectile-target interaction, respectively. The RP alumina was found to exhibit useful ballistic properties, successfully defeating steel-cored (AP) 7.62 × 39 mm BXN rounds at velocities of up-to c.a. 850 m/s, while exhibiting comparable failure modes to conventionally sintered armour-grade Sintox FA™. However, where a <1% by vol. Cu dopant was introduced into the RP material failure modes changed dramatically with performance dropping below that of conventionally sintered alumina. Overall, the results from both sets of experiments were complimentary and clearly indicated the potential of such RP materials to play an active role in provision of real-world body armour solutions provided quality control of the RP material can be maintained

Networks and the epidemiology of infectious disease

The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body of research concerning the spread of infectious diseases on networks, focusing on the interplay between network theory and epidemiology. The review is split into four main sections, which examine: the types of network relevant to epidemiology; the multitude of ways these networks can be characterised; the statistical methods that can be applied to infer the epidemiological parameters on a realised network; and finally simulation and analytical methods to determine epidemic dynamics on a given network. Given the breadth of areas covered and the ever-expanding number of publications, a comprehensive review of all work is impossible. Instead, we provide a personalised overview into the areas of network epidemiology that have seen the greatest progress in recent years or have the greatest potential to provide novel insights. As such, considerable importance is placed on analytical approaches and statistical methods which are both rapidly expanding fields. Throughout this review we restrict our attention to epidemiological issues

Sodium pumps mediate activity-dependent changes in mammalian motor networks

Funding: Laurence Picton [grant number BB/JO1446X/1] and Matthew Broadhead [grant number BB/M021793/1] were supported by the Biotechnology and Biological Science Research Council (BBSRC). Filipe Nascimento was supported by The Alfred Dunhill Links Foundation.Ubiquitously expressed sodium pumps are best known for maintaining the ionic gradients and resting membrane potential required for generating action potentials. However, activity- and state-dependent changes in pump activity can also influence neuronal firing and regulate rhythmic network output. Here we demonstrate that changes in sodium pump activity regulate locomotor networks in the spinal cord of neonatal mice. The sodium pump inhibitor, ouabain, increased the frequency and decreased the amplitude of drug-induced locomotor bursting, effects that were dependent on the presence of the neuromodulator dopamine. Conversely, activating the pump with the sodium ionophore monensin decreased burst frequency. When more "natural" locomotor output was evoked using dorsal-root stimulation, ouabain increased burst frequency and extended locomotor episode duration, whereas monensin slowed and shortened episodes. Decreasing the time between dorsal-root stimulation, and therefore interepisode interval, also shortened and slowed activity, suggesting that pump activity encodes information about past network output and contributes to feedforward control of subsequent locomotor bouts. Using whole-cell patch-clamp recordings from spinal motoneurons and interneurons, we describe a long-duration (∼60 s), activity-dependent, TTX- and ouabain-sensitive, hyperpolarization (∼5 mV), which is mediated by spike-dependent increases in pump activity. The duration of this dynamic pump potential is enhanced by dopamine. Our results therefore reveal sodium pumps as dynamic regulators of mammalian spinal motor networks that can also be affected by neuromodulatory systems. Given the involvement of sodium pumps in movement disorders, such as amyotrophic lateral sclerosis and rapid-onset dystonia parkinsonism, knowledge of their contribution to motor network regulation also has considerable clinical importance.Publisher PDFPeer reviewe

Antecedents of cybersecurity implementation: a study of the cyber-preparedness of U.K. social enterprises

The cyber-security of organisations is a subject of perennial concern as they are subject to mounting threats in an increasingly digitalised world. While commercial and charitable organizations have been the objects of cyber security research, Social Enterprises have remained unexplored. As Social Enterprises have become increasingly important features of social and economic development, so their prominence as potential targets of cybercrime also increases. In order to address this knowledge gap, this study examines the factors that influence the cyber-preparedness of Social Enterprises in the UK. Through the use of semi-structured interviews with Social Enterprise, these factors are found to comprise the characteristics of the enterprise, the characteristics of the enterprise management, resource constraints, experience of cyber attacks, usage of IT, and awareness of cybersecurity schemes and resources. These insights provide valuable guidance for SE owner-managers, SE support agencies and policy-makers when considering the cyber security of SEs. These findings are of immediate concern to social enterprises but also to other organizations that are engaged in partnerships with them as social enterprises may afford ‘gateway’ opportunities to those with malicious intent

Pinpointing needles in giant haystacks: use of text mining to reduce impractical screening workload in extremely large scoping reviews.

In scoping reviews, boundaries of relevant evidence may be initially fuzzy, with refined conceptual understanding of interventions and their proposed mechanisms of action an intended output of the scoping process rather than its starting point. Electronic searches are therefore sensitive, often retrieving very large record sets that are impractical to screen in their entirety. This paper describes methods for applying and evaluating the use of text mining (TM) technologies to reduce impractical screening workload in reviews, using examples of two extremely large-scale scoping reviews of public health evidence (choice architecture (CA) and economic environment (EE)). Electronic searches retrieved >800,000 (CA) and >1 million (EE) records. TM technologies were used to prioritise records for manual screening. TM performance was measured prospectively. TM reduced manual screening workload by 90% (CA) and 88% (EE) compared with conventional screening (absolute reductions of ≈430 000 (CA) and ≈378 000 (EE) records). This study expands an emerging corpus of empirical evidence for the use of TM to expedite study selection in reviews. By reducing screening workload to manageable levels, TM made it possible to assemble and configure large, complex evidence bases that crossed research discipline boundaries. These methods are transferable to other scoping and systematic reviews incorporating conceptual development or explanatory dimensions

The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions

The function of the human Tes protein, which has extensive similarity to zyxin in both sequence and domain organization, is currently unknown. We now show that Tes is a component of focal adhesions that, when expressed, negatively regulates proliferation of T47D breast carcinoma cells. Coimmunoprecipitations demonstrate that in vivo Tes is complexed with actin, Mena, and vasodilator-stimulated phosphoprotein (VASP). Interestingly, the isolated NH2-terminal half of Tes pulls out α-actinin and paxillin from cell extracts in addition to actin. The COOH-terminal half recruits zyxin as well as Mena and VASP from cell extracts. These differences suggest that the ability of Tes to associate with α-actinin, paxillin, and zyxin is dependent on the conformational state of the molecule. Consistent with this hypothesis, we demonstrate that the two halves of Tes interact with each other in vitro and in vivo. Using fibroblasts lacking Mena and VASP, we show that these proteins are not required to recruit Tes to focal adhesions. However, using RNAi ablation, we demonstrate that zyxin is required to recruit Tes, as well as Mena and VASP, but not vinculin or paxillin, to focal adhesions